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Title: Topical antiinflammatory activity of two pimarane diterpenes from Kaempferia pulchra
Authors: Ubonwan Pongprayoon
Tuanta Sematong
Patoomratana Tuchinda
Per Claeson
Vichai Reutrakul
Nilufar Nahar
Thailand Ministry of Science and Technology
Mahidol University
University of Dhaka
Keywords: Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-1996
Citation: Phytotherapy Research. Vol.10, No.6 (1996), 534-535
Abstract: Two diterpenes, 2α-acetoxysandraracopimaradien-1α-ol (1) and sandaracopimaradien-1α,2α-diol (2) isolated from Kaempferia pulchra Ridl. (Zingiberaceae), have been assayed for topical antiinflammatory activity in the model of 12-O-tetradecanoylphorbol-13-acetate-induced ear oedema in rats. Both substances were found active and the ID50-values were estimated to be 330 and 50 μg/ear, respectively. The ID50-value of the reference drug diclofenac was calculated to 90 μg/ear.
ISSN: 0951418X
Appears in Collections:Scopus 1991-2000

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