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Title: Immunohistochemical characterization of a new monoclonal antibody reactive with dengue virus-infected cells in frozen tissue using immunoperoxidase technique
Authors: Lertlakana Bhoopat
Natth Bhamarapravati
Chaninya Attasiri
Suthee Yoksarn
Benjaporn Chaiwun
Surapan Khunamornpong
Virat Sirisanthana
Chiang Mai University
Mahidol University
Faculty of Medicine, Thammasat University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Dec-1996
Citation: Asian Pacific Journal of Allergy and Immunology. Vol.14, No.2 (1996), 107-113
Abstract: This paper presents a novel monoclonal antibody shown to react with cytoplasmic antigens in various dengue infected human frozen organs from autopsy and necropsy specimens. Strong reactivity was found in hematopoietic cells, including immunoblasts, lymphocytes, plasma cells and macrophages of spleen, lymph node, lung, kidney and stomach. Strikingly, strong positivity was demonstrated in cerebral cortex neurones, Purkinje cells, choroid plexus and blood vessels in addition to astrocytes and microglia. Neurotropism of the virus could explain the meningitis, encephalitis, mononeuropathy and polyneuropathy observed by direct toxicity, but noted especially after an activation of mononuclear phagocytes and amplification of the immune response with subsequent vascular inflammation and formation of immune complexes.
ISSN: 0125877X
Appears in Collections:Scopus 1991-2000

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