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Title: Langerhans cell density and serological changes following intradermal immunisation of mice with dengue 2 virus
Authors: Suwimol Taweechaisupapong
Siriporn Sriurairatana
Subhkij Angsubhakorn
Sutee Yoksan
Mi Mi Khin
Somphong Sahaphong
Natth Bhamarapravati
Mahidol University
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-1996
Citation: Journal of Medical Microbiology. Vol.45, No.2 (1996), 138-145
Abstract: After the introduction of the dengue-2 (16681) virus by intradermal (i.d.) injection into the footpads of mice, Langerhans cells (LCs) increased in numbers within 24 h at the site of injection and neutralising antibody developed. On comparing the i.d. and intramuscular (i.m.) routes, antibody was produced more rapidly and at higher levels when the virus was injected by the i.d. route. Subsequent re-challenge by the i.d. route produced an even more rapid serological response with all mice producing significant neutralising titres within 12 h. Numbers of ATPase-positive LCs varied with time. A significant sharp drop in LC densities in the early post-injection phase directly correlated with the increased numbers of dendritic cells in the superficial dermis and interfollicular sinuses of draining lymph nodes (LN). Immunofluorescence showed the presence of viral antigen in the footpad epidermis and draining LN within minutes or within 2 h of challenge, respectively.
ISSN: 00222615
Appears in Collections:Scopus 1991-2000

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