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dc.contributor.authorSansanee C. Chaiyarojen_US
dc.contributor.authorPornpimon Angkasekwinaien_US
dc.contributor.authorAkanit Buranakitien_US
dc.contributor.authorSornchai Looareesuwanen_US
dc.contributor.authorStephen J. Rogersonen_US
dc.contributor.authorGraham V. Brownen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherWalter and Eliza Hall Institute of Medical Researchen_US
dc.identifier.citationAmerican Journal of Tropical Medicine and Hygiene. Vol.55, No.1 (1996), 76-80en_US
dc.description.abstractThe association between cytoadherence of Plasmodium falciparum-infected erythrocytes and the severity of malaria has been evaluated. In this study, we investigate adherence to C32 melanoma cells, CD36, intracellular adhesion molecule-1 (ICAM-1), thrombospondin (TSP), E-selectin, vascular cell adhesion molecule-1 (VCAM-1), and chondroitin sulfate A (CSA) of 36 P. falciparum isolates from patients suffering from acute falciparum malaria. Adherence to purified adhesion molecules varied greatly among different parasite isolates. All isolates but one adhered to CD36, but none bound to E-selectin and VCAM-1 beyond control levels. Some P. falciparum isolates adhered to ICAM-1 and to CSA, a newly identified receptor for adherence. There was no correlation between in vitro binding to any one receptor and the patients' conditions. In addition, we investigated the characteristics of adherence to CSA and to C32 melanoma cells. Infected erythrocytes continued to adhere after trypsin digestion and soluble CSA inhibited adherence to C32 melanoma cells in a dose-dependent manner. The results imply a role for CSA in the natural infection of P. falciparum.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleCytoadherence characteristics of Plasmodium falciparum isolates from Thailand: Evidence for chondroitin sulfate a as a cytoadherence receptoren_US
Appears in Collections:Scopus 1991-2000

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