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Title: Evaluation of the effect of vitamin A-fortified margarine on the vitamin A status of preschool Filipino children
Authors: F. S. Solon
M. S. Solon
H. Mehansho
K. P. West
J. Sarol
C. Perfecto
T. Nano
L. Sanchez
M. Isleta
E. Wasantwisut
A. Sommer
Nutrition Center of the Philippines
Procter and Gamble
Johns Hopkins Bloomberg School of Public Health
University of the Philippines System
Mahidol University
Keywords: Medicine;Nursing
Issue Date: 1-Nov-1996
Citation: European Journal of Clinical Nutrition. Vol.50, No.11 (1996), 720-723
Abstract: Objectives: This study assessed the effects of consuming a highly hydrogenated, vitamin A (VA)-fortified margarine not requiring refrigeration on VA status of preschool children. Design: A double-masked randomized community trial. Setting: Six rural villages in Cavite, Southern Luzon, the Philippines. Subjects: 296 and 285 children 3-6 y of age in the VA-fortified (experimental) and non-fortified (control) margarine groups, respectively. Intervention: Each week for 6 months households were given 250 g of VA-fortified margarine [providing 28.8 μg retinol equivalents (RE) per g] or non-fortified (0 μg RE) margarine of identical appearance for each enrolled child. Children's vitamin A status [serum retinol, xerophthalmia, and conjunctival impression cytology (CIC) status] and dietary intake were assessed at baseline and folloiv-up; margarine intake was monitored throughout the study. Results: Daily margarine intake per child averaged 27 g in the experimental group (providing 776 μg RE) and 24 g (0 μg RE) in the control group. After 6 months, mean serum retinol increased from 26.4 to 28.8 μg/dl in the experimental group but decreased from 26.6 to 25.1 μg/dl in controls (P < 0.001 at 6 months); the multiple-adjusted increment over controls was 2.4 μg/dl (P < 0.01). More importantly, the prevalence of low serum retinol (< 20 μg/dl) decreased from 25.7 to 10.1% in the experimental group but remained unchanged in controls (26.7 to 27.7%) (P < 0.01 at 6 months). At follow-up no experimental children had developed xerophthalmia but 1.4 and 1.8% of controls developed nightblindness and Bitot's spots, respectively. There were no differences in CIC between groups. Conclusion: Consumption of VA-fortified margarine significantly improved VA status of preschool Filipino children.
ISSN: 09543007
Appears in Collections:Scopus 1991-2000

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