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Title: Oral contraceptives and invasive adenocarcinomas and adenosquamous carcinomas of the uterine cervix
Authors: David B. Thomas
Roberta M. Ray
Geoffrey Berry
Robert MacLennan
Rodney Shearman
Tatiana Jelihovsky
Joan Cooper Booth
Ramiro Molina
Luis Martinez
Oriana Salas
Alfredo Dabancens
Alvaro Cuadros
Nubia Aristizabal
Baruch Modan
Elaine Ron
Esther Alfandary
J. G. Mati
Patrick Kenya
Alfred Kungu
D. Gatei
Hector Rodriguez Cuevas
Socorro Benavides Salazar
Antonio Palet
Patricia Ontiveros
Ruben A. Apelo
Julietta R. De La Cruz
Jose Baens
Benjamin D. Canlas
Suporn Silpisornkosol
Tieng Pardthaisong
Viruch Charoeniam
Choti Theetranont
Banpot Boosiri
Supawat Chutivongse
Pramuan Virutamasen
Chansuda Wongsrichanalai
Sermsri Sindhavananda
Suporn Koetsawang
Duangdao Rachawat
Amorn Koetsawang
Gustave Riotton
William M. Christopherson
Joseph L. Melnick
Ervin Adam
Olav Meirik
Timothy M.M. Farley
Susan Holck
Fred Hutchinson Cancer Research Center
The University of Sydney
Hospital Universitario
Chaim Sheba Medical Center Israel
University of Nairobi
Hospital General de Mexico
University of the Philippines Manila
Chiang Mai University
Chulalongkorn University
Mahidol University
Universite de Geneve Faculte de Medecine
University of Louisville Health Sciences Center
Baylor College of Medicine
Organisation Mondiale de la Sante
Keywords: Medicine
Issue Date: 1-Aug-1996
Citation: American Journal of Epidemiology. Vol.144, No.3 (1996), 281-289
Abstract: Data from a hospital-based case-control study collected between 1979 and 1988 in 10 participating hospitals in eight countries were analyzed to determine whether use of combined oral contraceptives alters the risks of invasive adenocarcinomas and adenosquamous carcinomas of the uterine cervix. Information on prior use of oral contraceptives, suspected risk factors for cervical cancer, and history of cytologic screening was ascertained from interviews with 271 women with adenocarcinomas, 106 with adenosquamous carcinomas, and a large pool of hospitalized controls, from which 2,887 were matched to the cases included in this report. History of smoking and anogenital warts and blood specimens for measurement of herpes simplex and cytomegalovirus antibodies were obtained from subsets of these women, as was a sexual history from a subset of their husbands. The epidemiologic features and associations with oral contraceptives were similar for adenocarcinoma and adenosquamous carcinoma. For both types combined, risk increased with duration of oral contraceptive use, was highest in recent and current users, and declined with time since cessation of use. These trends in risk were strongest for cancers that occurred in women under age 35 years, and the association with risk was somewhat stronger for high compared with low progestin potency products. The strength of the observed relation with oral contraceptives was about the same as has been observed for invasive squamous cell cervical carcinomas. Women who have used oral contraceptives should be considered at increased risk of adenomatous cervical carcinomas.
ISSN: 00029262
Appears in Collections:Scopus 1991-2000

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