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|Title:||Novel cytotoxic 1H-cyclopenta[b]benzofuran lignans from Aglaia elliptica|
Norman R. Farnsworth
Geoffrey A. Cordell
John M. Pezzuto
A. Douglas Kinghorn
University of Illinois at Chicago
The Forest Herbarium, Thailand Ministry of Natural Resources and Environment
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Tetrahedron. Vol.53, No.52 (1997), 17625-17632|
|Abstract:||Bioassay-guided fractionation of the stems and fruits of Aglaia elliptica using human oral epidermoid carcinoma (KB) cells, led to the isolation of five cyclopenta[b]benzofurans, constituted by methyl rocaglate (1) and four novel compounds (2-5), along with three known dammarane triterpenoids. Compound 5 possesses an unusual formyl ester substituent at the C-1 position. The structures of the novel compounds were established on the basis of spectroscopic methods. Compounds 1-5 were found to be very potent cytotoxic substances when evaluated against a panel of human cancer cell lines.|
|Appears in Collections:||Scopus 1991-2000|
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