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Title: Novel cytotoxic 1H-cyclopenta[b]benzofuran lignans from Aglaia elliptica
Authors: Baoliang Cui
Heebyung Chai
Thawatchai Santisuk
Vichai Reutrakul
Norman R. Farnsworth
Geoffrey A. Cordell
John M. Pezzuto
A. Douglas Kinghorn
University of Illinois at Chicago
The Forest Herbarium, Thailand Ministry of Natural Resources and Environment
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 29-Dec-1997
Citation: Tetrahedron. Vol.53, No.52 (1997), 17625-17632
Abstract: Bioassay-guided fractionation of the stems and fruits of Aglaia elliptica using human oral epidermoid carcinoma (KB) cells, led to the isolation of five cyclopenta[b]benzofurans, constituted by methyl rocaglate (1) and four novel compounds (2-5), along with three known dammarane triterpenoids. Compound 5 possesses an unusual formyl ester substituent at the C-1 position. The structures of the novel compounds were established on the basis of spectroscopic methods. Compounds 1-5 were found to be very potent cytotoxic substances when evaluated against a panel of human cancer cell lines.
ISSN: 00404020
Appears in Collections:Scopus 1991-2000

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