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Title: Novel cytotoxic ring-A seco-cycloartane triterpenes from Gardenia coronaria and G. sootepensis
Authors: Gloria L. Silva
Roberto R. Gil
Baoliang Cui
Heebyung Chai
Thawatchai Santisuk
Ekarath Srisook
Vichai Reutrakul
Patoomratana Tuchinda
Smaisukh Sophasan
Suparp Sujarit
Suchart Upatham
Sean M. Lynn
John E. Farthing
Shi Lin Yang
Jane A. Lewis
Melanie J. O'Neill
Norman R. Farnsworth
Geoffrey A. Cordell
John M. Pezzuto
A. Douglas Kinghorn
University of Illinois at Chicago
The Forest Herbarium, Thailand Ministry of Natural Resources and Environment
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 13-Jan-1997
Citation: Tetrahedron. Vol.53, No.2 (1997), 529-538
Abstract: Coronalolide methyl ester (1), coronalolide (2), and coronalolic acid (3) were isolated from the leaves and/or stems of Gardenia coronaria. A further compound, methyl coronalolate acetate (4), was purified from the stems after methylation. The novel compounds 1-4 have the rare ring-A seco-cycloartane carbon skeleton and their structures were assigned on the basis of spectral data and molecular modeling, as well as X-ray crystallography performed on 1. Compounds 1 and 2 were also isolated from the leaves of Gardenia sootepensis and showed broad cytotoxic activity when evaluated against a panel of human cancer cell lines.
ISSN: 00404020
Appears in Collections:Scopus 1991-2000

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