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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/17959
Title: High prevalence of hepatitis G viremia among kidney transplant patients in Thailand
Authors: Boonyos Raengsakulrach
Leena Ong-aj-yooth
Thanarak Thaiprasert
Sanga Nilwarangkur
Sompong Ong-aj-yooth
Sumitda Narupiti
Vipa Thirawuth
Chonticha Klungthong
Rapin Snitbhan
David W. Vaughn
Armed Forces Research Institute of Medical Sciences, Thailand
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Oct-1997
Citation: Journal of Medical Virology. Vol.53, No.2 (1997), 162-166
Abstract: Patients receiving kidney transplants (KT) are at high risk for blood borne viral infections. To determine the prevalence of a recently discovered hepatitis G virus (HGV) in this patient group, reverse transcription-polymerase chain reaction (RT-PCR) employing primers derived from the NS5 region of the viral genome was utilized. HGV RNA was detected in 40 of 94 KT patients (43%), as compared to 3 of 69 healthy subjects (4.3%). Cocirculation of HGV and hepatitis C virus (HCV) RNA was detected in 12 patients (13%). Comparison of patients with and without HGV revealed that the former had received hemodialysis before transplantation for a significantly longer duration than the latter (28 vs. 17 months, respectively; P < 0.05). The amount of blood transfused and mean levels of liver enzymes, including alkaline phosphatase, alanine transaminase, and aspartate transaminase, were the same in both groups. Sequence analysis of 275-base pair DNA clones obtained from 2 patients revealed approximately 92% sequence homology to the published HGV and GB virus C sequences. These results suggested that HGV infection among Thai KT patients was high and the role of HGV in causing liver disease remains to be determined.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0030765912&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/17959
ISSN: 01466615
Appears in Collections:Scopus 1991-2000

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