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Title: Involvement of cytokines in the histopathology of cerebral malaria
Authors: Rachanee Udomsangpetch
Songpol Chivapat
Parnpen Viriyavejakul
Mario Riganti
Polrat Wilairatana
Emsri Pongponratn
Sornchai Looareesuwan
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-1997
Citation: American Journal of Tropical Medicine and Hygiene. Vol.57, No.5 (1997), 501-506
Abstract: Histopathologic and immunohistologic studies were performed in two cases of fatal cerebral malaria. On admission, both patients were in unarousable coma with hyperparasitemia. Examination of the tissue sections from various organs showed parasite sequestration in both cases with more extensive area of sequestration in case 1 than in case 2. A panel of monoclonal antibodies against cytokines applied to these tissues clearly detected tumor necrosis factor-alpha (TNFα), interferon-gamma (IFNγ), interleukin-1B (IL-1β), and IL-10 in the tissues from brain and liver of case 1. A different cytokine profile, IL-4 and IL-10, was found in the brain tissues of case 2; no TNFα nor IFNγ was detected. There was no cytokine detected in the tissues of other organs in either case. Results of the study suggest that histopathology in the brain of fatal cerebral malaria may be associated with focal accumulation of cytokines. Additionally, the type of cytokines produced locally in a particular tissue during malaria infection may be regulated by the degree of regional parasite sequestration.
ISSN: 00029637
Appears in Collections:Scopus 1991-2000

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