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Title: Remission of refractory gestational trophoblastic disease in the brain with ifosfamide, carboplatin, and etoposide (ICE): First report and review of literature
Authors: Surintip Piamsomboon
Andrzej P. Kudelka
Wichai Termrungruanglert
Koen Van Besien
Creyhton L. Edwards
Samuel Lifshitz
Donald F. Schomer
Richard Champlin
Rosario P. Mante
John J. Kavanagh
Claire F. Verschraegen
Mahidol University
University of Texas MD Anderson Cancer Center
Chulalongkorn University
Presbyterian Hospital of Dallas
Keywords: Medicine
Issue Date: 17-Dec-1997
Citation: European Journal of Gynaecological Oncology. Vol.18, No.6 (1997), 453-456
Abstract: Gestational trophoblastic disease (GTD) metastatic to the brain has a very poor prognosis with a survival rate of less than 25%, especially for patients in whom brain metastases develop while on or after chemotherapy. Cure can be achieved by chemotherapy alone. The regimen of etoposide, methotrexate, actinomycin-D, vincristine, and cyclophosphamide has shown encouraging results and is considered to be standard first-line treatment for high risk patients. For patients in whom this regimen fails, a salvage chemotherapy regimen is used. The combination of ifosfamide, carboplatin, and etoposide (ICE) has synergistic activity in preclinical studies. This regimen has shown activity in metastatic breast cancer and non-small-cell lung cancer as well as platinum-resistant germ-cell tumors and metastatic GTD. This is the first report of a patient with a highly refractory GTD in whom brain metastasis developed while on chemotherapy, and whose brain metastasis went into remission with a low dose ICE regimen. Accordingly, ICE may be considered for patients with chemotherapy refractory GTD metastatic to the brain.
ISSN: 03922936
Appears in Collections:Scopus 1991-2000

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