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dc.contributor.authorSurintip Piamsomboonen_US
dc.contributor.authorAndrzej P. Kudelkaen_US
dc.contributor.authorWichai Termrungruanglerten_US
dc.contributor.authorKoen Van Besienen_US
dc.contributor.authorCreyhton L. Edwardsen_US
dc.contributor.authorSamuel Lifshitzen_US
dc.contributor.authorDonald F. Schomeren_US
dc.contributor.authorRichard Champlinen_US
dc.contributor.authorRosario P. Manteen_US
dc.contributor.authorJohn J. Kavanaghen_US
dc.contributor.authorClaire F. Verschraegenen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Texas MD Anderson Cancer Centeren_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherPresbyterian Hospital of Dallasen_US
dc.identifier.citationEuropean Journal of Gynaecological Oncology. Vol.18, No.6 (1997), 453-456en_US
dc.description.abstractGestational trophoblastic disease (GTD) metastatic to the brain has a very poor prognosis with a survival rate of less than 25%, especially for patients in whom brain metastases develop while on or after chemotherapy. Cure can be achieved by chemotherapy alone. The regimen of etoposide, methotrexate, actinomycin-D, vincristine, and cyclophosphamide has shown encouraging results and is considered to be standard first-line treatment for high risk patients. For patients in whom this regimen fails, a salvage chemotherapy regimen is used. The combination of ifosfamide, carboplatin, and etoposide (ICE) has synergistic activity in preclinical studies. This regimen has shown activity in metastatic breast cancer and non-small-cell lung cancer as well as platinum-resistant germ-cell tumors and metastatic GTD. This is the first report of a patient with a highly refractory GTD in whom brain metastasis developed while on chemotherapy, and whose brain metastasis went into remission with a low dose ICE regimen. Accordingly, ICE may be considered for patients with chemotherapy refractory GTD metastatic to the brain.en_US
dc.rightsMahidol Universityen_US
dc.titleRemission of refractory gestational trophoblastic disease in the brain with ifosfamide, carboplatin, and etoposide (ICE): First report and review of literatureen_US
Appears in Collections:Scopus 1991-2000

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