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Title: Detection and typing of human papilloma virus DNAs in normal cervix, intraepithelial neoplasia and cervical cancer in Bangkok
Authors: Sontana Siritantikorn
Somsak Laiwejpithaya
Uamporn Siripanyaphinyo
Prasert Auewarakul
Pa Thai Yenchitsomanus
Kleophant Thakernpol
Chantapong Wasi
Mahidol University
Keywords: Medicine
Issue Date: 1-Dec-1997
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.28, No.4 (1997), 707-710
Abstract: We detected and typed HPV-DNA by polymerase chain reaction (PCR) in cervico-vaginal lavages of 102 women with normal cervical cytology, 57 patients with cervical intraepithelial neoplasia (CIN), and 23 cervical cancer patients. HPV-DNA detection and typing by in situ hybridization were also performed in cervical biopsies from CIN lesions and cancers. Five percent of women with normal cervical cytology, 46% of CIN, and 61% of cervical cancer were positive for HPV-DNA. Of CIN cases with positive HPV-DNA, 69, 15, 8, 4 and 4% were HPV-16, -33, -18, -11 and -16/33 respectively. Of cervical cancer cases with positive HPV-DNA, 86% were HPV-16, 7% were HPV-16/33, 7% were HPV-18/31. HPV typing was performed in biopsies from 37 CIN and 18 cervical cancers by In situ hybridization. By this method, 38% of CIN were HPV-DNA positive, of which 71% were HPV-16 and 7% were each of HPV-11, -18, -31 and -33. Thirty-nine percent of cevical cancers were positive, of which 71% and 29% were HPV-16 and HPV-16/18 respectively.
ISSN: 01251562
Appears in Collections:Scopus 1991-2000

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