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http://repository.li.mahidol.ac.th/dspace/handle/123456789/18046| Title: | Maternal and viral factors in vertical transmission of HIV-1 subtype E |
| Authors: | Ruengpung Sutthent Suporn Foongladda Sanay Chearskul Niran Wanaprapa Sirirat Likanonskul Uraiwan Kositanont Suda Riengrojpitak Somphong Sahapong Chantapong Wasi Mahidol University Bamrasnadura Hospital Faculty of Medicine, Siriraj Hospital, Mahidol University |
| Keywords: | Medicine |
| Issue Date: | 1-Dec-1997 |
| Citation: | Southeast Asian Journal of Tropical Medicine and Public Health. Vol.28, No.4 (1997), 689-698 |
| Abstract: | Vertical transmission of HIV-1 is caused by multifactorial factors. To access the relationship of viral factors involving in perinatal transmission of HIV-1 subtype E, which is the predominant type in Thailand, plasma viral load, blood CD4+ lymphocyte level, heteroduplex mobility, and V3 sequence of the HIV-1 envelope gene were studied in 32 transmitting and 25 non-transmitting mothers. We found that HIV-1 subtype E vertical transmission was strongly associated with high maternal plasma viral RNA (> 4 × 104 copies/ml) and high genetic diversity of envelope gene determined by heteroduplex mobility (< 0.9). The variation of nucleotide sequences in envelope gene of subtype E vertical transmission could not determine in V3 region. Hence, plasma viral load and heteroduplex mobility can be used as prediction factors in vertical transmission of HIV-1 subtype E. |
| URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0031301530&origin=inward http://repository.li.mahidol.ac.th/dspace/handle/123456789/18046 |
| ISSN: | 01251562 |
| Appears in Collections: | Scopus 1991-2000 |
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