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dc.contributor.authorPunnee Butthepen_US
dc.contributor.authorArchrob Khuhapinanten_US
dc.contributor.authorAhnond Bunyaratvejen_US
dc.contributor.authorSuthat Fucharoenen_US
dc.contributor.authorHiromichi Kitaguchien_US
dc.contributor.authorYoshinori Funaharaen_US
dc.contributor.otherFaculty of Medicine, Ramathibodi Hospital, Mahidol Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherKobe University School of Medicineen_US
dc.identifier.citationSoutheast Asian Journal of Tropical Medicine and Public Health. Vol.28, (1997), 155-160en_US
dc.description.abstractHuman umbilical vein endothelial cells were cultured in vitro using Iscove's Modified Dulbecco's Medium (IMDM) supplemented with either pooled normal human serum, or pooled thalassemic serum, or autologous umbilical cord serum, or fetal bovine serum. The mitotic activity was determined under the inverted phase contrast microscope and the number of mitotic cells was counted. Our results showed that the mitotic cells decreased in endothelial cell culture with thalassemic serum as compared with normal human serum, autologous umbilical cord serum or fetal bovine serum. The percentage of mitotic cells decreased on day 3 in the presence of β-thalassemia/HbE serum from both splenectomized and non-splenectomized patients as compared with normal or autologous umbilical cord serum. In the presence of α-thalassemic serum, a similar outcome was also observed. From this study we can conclude that the thalassemic sera might contain factors which affect the endothelial cell growth and proliferation by inhibiting mitosis in vitro.en_US
dc.rightsMahidol Universityen_US
dc.titleThalassemic serum inhibits endothelial cell mitosis in vitroen_US
Appears in Collections:Scopus 1991-2000

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