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|Title:||The involvement of microglial cells in japanese encephalitis infections|
Smith, Duncan R.
Mahidol University. Faculty of Medicine. Department of Microbiology.
Mahidol University. Institute of Molecular Biosciences. Molecular Pathology Laboratory
Mahidol University. Center for Emerging and Neglected Infectious Diseases
|Keywords:||Involvement;Microglial Cells;Japanese;Encephalitis;Infections;Open Access article|
|Citation:||Clinical and Developmental Immunology. 2012, ID 890586|
|Abstract:||Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases admitted to hospital die and 50% of the survivors suffer from neurological sequelae. Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection.|
|Appears in Collections:||MB-Article|
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