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Title: The involvement of microglial cells in japanese encephalitis infections
Authors: Thananya Thongtan
Chutima Thepparit
Smith, Duncan R.
Mahidol University. Faculty of Medicine. Department of Microbiology.
Mahidol University. Institute of Molecular Biosciences. Molecular Pathology Laboratory
Mahidol University. Center for Emerging and Neglected Infectious Diseases
Keywords: Involvement;Microglial Cells;Japanese;Encephalitis;Infections;Open Access article
Issue Date: 2012
Citation: Clinical and Developmental Immunology. 2012, ID 890586
Abstract: Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases admitted to hospital die and 50% of the survivors suffer from neurological sequelae. Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection.
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