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Title: Increasing the Chance to Accept HLA-ABDR Mismatched Donor in Kidney Transplantation
Authors: Kanchana Sujirachato
Pimol Chiewsilp
Tasanee Mongkolsuk
Sureeporn Junpong
Vasant Sumethkul
Sopon Jirasiritham
Suthus Sriphojanart
Siroj Kanjanapanjapol
Somnuek Domrongkitchaiporn
Mahidol University
Keywords: Medicine
Issue Date: 1-Sep-1997
Citation: Journal of the Medical Association of Thailand. Vol.80, No.SUPPL. 1 (1997)
Abstract: Two hundred and fifty-three kidney transplantations (KT) which included 68 (26.9%) living-related (L) and 185 (73.1%) cadaveric (C) KT with 0-6 KDLA-ABDR mismatches (MM) were studied for the association of HLA-ABDR-MM specificities and the occurrence of graft rejection (GR). It was found that the incidence of acute and chronic rejection in CKT was significantly higher than that of LKT (42.1% vs 22.1%, p<0.005). It was also observed that the number of ABDR-MM, AB-MM and BDR-MM which is important in GR were 2 times in CKT compared with LKT. The analysis revealed that HLA-A11, B16, B22, B35, B5, B17 and DR3 were good responders, whereas, HLA-A30, A2, B62, B18, B40, B44, B46 and DR10 were good stimulators for KT. GR were significantly increased with p<0.01 and <0.05, respectively. Specific HLA-MM specificities played a significant role in GR, i.e., some HLA-MM specificities were permissible, whereas, some were immunogenic. Careful selection of donor and recipient for KT by avoiding immunogenic HLA-MM and/or accepting permissible HLA-MM will improve graft survival and reduce the demand of kidney for retransplantation.
ISSN: 01252208
Appears in Collections:Scopus 1991-2000

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