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Title: Bone marrow and cord blood stem cell transplantation for thalassemia in Thailand
Authors: S. Issaragrisil
V. Suvatte
S. Visuthisakchai
V. S. Tanphaichitr
D. Chandanayingyong
V. Chongkolwatana
Y. U-pratya
M. Yimyam
C. Mahasandana
Mahidol University
Faculty of Medicine, Siriraj Hospital, Mahidol University
Keywords: Medicine
Issue Date: 1-Mar-1997
Citation: Bone Marrow Transplantation. Vol.19, No.SUPPL. 2 (1997), 54-56
Abstract: Thalassemias and hemoglobinopathies are prevalent in Thailand. Bone marrow transplantation is the only curative therapy for thalassemia. We report 28 transplants in 26 patients with thalassemia. Twenty-one patients underwent bone marrow transplantation after conditioning with busulfan 14 mg/kg and cyclophosphamide 200 mg/kg. The outcome was favorable in those with hepatomegaly and splenomegaly ≤ 2 cm below costal margin. Graft rejection is a problem in the patients who have severe manifestations as determined by enlargement of liver and spleen > 2 cm below costal margin. A higher dose of busulfan 600 mg/m2 was used in seven patients who had severe manifestations with success. Cord blood is an alternative source of stem cells for transplant. Cord blood was collected from HLA-identical unaffected neonates and used for transplant into affected siblings. Five out of 6 pateints who underwent cord blood transplantation are alive and well.
ISSN: 02683369
Appears in Collections:Scopus 1991-2000

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