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Title: Levonorgestrel concentrations during use of levonorgestrel rod (LNG ROD) implants
Authors: Irving Sivin
Pekka Lähteenmäki
Sirpa Ranta
Philip Darney
Cindy Klaisle
Livia Wan
Daniel R. Mishell
Maria Lacarra
Osborn A.C. Viegas
Prapas Bilhareus
Suporn Koetsawang
Manee Piya-Anant
Soledad Diaz
Margarita Pavez
Francisco Alvarez
Vivian Brache
Katherine LaGuardia
Harold Nash
Janet Stern
Population Council Headquarters
Helsingin Yliopisto
Bellevue Hospital Center
Keck School of Medicine of USC
National University of Singapore
Mahidol University
Instituto Chileno de Medicina Reproductiva
Asoc. Pro Bienstar de la Familia
Weill Graduate School of Medical Sciences
Keywords: Medicine
Issue Date: 1-Feb-1997
Citation: Contraception. Vol.55, No.2 (1997), 81-85
Abstract: In a three-year randomized trial that included 398 women, blood samples were collected for the purpose of assaying levonorgestrel concentrations in women using a new two-rod contraceptive implant system or an earlier implant formulation, Norplant®-2 implants. Sample collection was at 1, 3, 6, 9, and 12 months after placement and semiannually thereafter through three years. Resulting assays and analyses showed that levonorgestrel concentrations of each implant formulation decreased significantly with time after placement, with increasing body weight, and with ponderal index. In the third year, several measures indicated that concentrations of the contraceptive drug were higher in women using the LNG ROD implants than in users of the original formulation. No pregnancies occurred among women in either group in the three years. This study provides evidence that the minimum levonorgestrel concentration needed to protect against pregnancy is below 200 pg/ml, and possibly is below 175 pg/ml.
ISSN: 00107824
Appears in Collections:Scopus 1991-2000

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