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Title: Complete remission of refractory gestational trophoblastic disease with brain metastases treated with multicycle ifosfamide, carboplatin, and etoposide (ICE) and stem cell rescue
Authors: Koen Van Besien
Claire Verschraegen
Rakesh Mehra
Sergio Giralt
Andrzej P. Kudelka
Creighton L. Edwards
Surintip Piamsonboom
Wichai Termrungruanglert
Richard Champlin
John J. Kavanagh
University of Texas MD Anderson Cancer Center
Mahidol University
Chulalongkorn University
Keywords: Medicine
Issue Date: 1-Jan-1997
Citation: Gynecologic Oncology. Vol.65, No.2 (1997), 366-369
Abstract: Patients with chemotherapy-refractory gestational trophoblastic disease and brain metastasis are considered to have a very poor prognosis. We present the case of a patient who had failed several chemotherapeutic regimens. Despite transient responses to chemotherapy, she had not achieved a complete remission in 3 years, and had developed systemic disease and recurrent brain metastasis. She was treated with four cycles of high-dose ifosfamide, carboplatin, and etoposide with blood progenitor cell support. She tolerated this regimen well and has obtained a complete remission that is ongoing for 12 months.
ISSN: 00908258
Appears in Collections:Scopus 1991-2000

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