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http://repository.li.mahidol.ac.th/dspace/handle/123456789/18254| Title: | Limonoids from Azadirachta excelsa |
| Authors: | Baoliang Cui Heebyung Chai Howard L. Constant Thawatchai Santisuk Vichai Reutrakul Christopher W.W. Beecher Norman R. Farnsworth Geoffrey A. Cordell John M. Pezzuto A. Douglas Kinghorn University of Illinois at Chicago The Forest Herbarium, Thailand Ministry of Natural Resources and Environment Mahidol University |
| Keywords: | Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology |
| Issue Date: | 1-Apr-1998 |
| Citation: | Phytochemistry. Vol.47, No.7 (1998), 1283-1287 |
| Abstract: | Activity-directed fractionation of a stem extract of Azadirachta excelsa using KB (human oral epidermoid carcinoma) cells led to the isolation of four meliacin-type limonoids. Two of these constituents were novel, namely, 2,3- dihydronimbolide and 3-deoxymethylnimbidate, and these were purified along with the known compounds, nimbolide and 28-deoxonimbolide. The structures of the new compounds were determined by spectroscopic methods. Nimbolide and 28- deoxonimbolide were broadly cytotoxic when evaluated against a panel of human cancer cell lines, while the two novel compounds were inactive in this regard. The defection of nimbolide and 28-deoxonimbolide as cytotoxic constituents was facilitated by an electrospray LC/MS dereplication procedure. |
| URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0032051786&origin=inward http://repository.li.mahidol.ac.th/dspace/handle/123456789/18254 |
| ISSN: | 00319422 |
| Appears in Collections: | Scopus 1991-2000 |
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