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Title: Hematopoietic progenitor cells in the blood and bone marrow in various hematologic disorders.
Authors: S. Issaragrisil
Y. U-pratya
M. Yimyam
K. Pakdeesuwan
A. Khuhapinant
W. Muangsup
K. Pattanapanyasat
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Dec-1998
Citation: Stem cells (Dayton, Ohio). Vol.16 Suppl 1, (1998), 123-128
Abstract: Hematopoietic progenitor cells are present in the blood and the bone marrow. Changes in the numbers of hematopoietic progenitor cells reflect alteration of pluripotent stem cells. We discuss such changes in common hematologic diseases including aplastic anemia, paroxysmal nocturnal hemoglobinuria (PNH) and thalassemia. In aplastic anemia, the numbers of burst forming units-erythroid (BFU-E) and colony-forming units-granulocyte-macrophage (CFU-GM) are much decreased; the decrease still exists after recovery from therapy. In PNH, the numbers of progenitor cells are low, even in the presence of marrow hypercellularity. In thalassemia, the numbers of progenitor cells are much increased; more pronounced in splenectomized patients.
ISSN: 10665099
Appears in Collections:Scopus 1991-2000

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