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Title: A serotyping assay for hepatitis C virus in Southeast Asia
Authors: Sirirurg Songsivilai
Duangjit Kanistanon
Tararaj Dharakul
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 1-Dec-1998
Citation: Clinical and Diagnostic Laboratory Immunology. Vol.5, No.5 (1998), 737-739
Abstract: A serotyping assay for hepatitis C virus (HCV) was evaluated with samples from Thailand, where the distribution of HCV genotypes was different from that in Western countries where the assay was designed and validated. The sensitivity of the assay was low (58%) for HCV RNA-positive samples compared to that of the genotyping assay (95%, P < 0.01). In addition, only 36% of anti-HCV-positive but HCV RNA-negative samples could be serotyped. The serotypes and genotypes were identical in 96% of the samples that could be typed by both methods. Most of the samples with genotype 6, which was common in Southeast Asia, were nontypeable by this serotyping assay.
ISSN: 1071412X
Appears in Collections:Scopus 1991-2000

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