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Title: Hydrogen peroxide toxicity induces ras signaling in human neuroblastoma SH-SY5Y cultured cells
Authors: Jirapa Chetsawang
Piyarat Govitrapong
Banthit Chetsawang
Mahidol University. Institute of Molecular Biosciences. Research Center for Neuroscience
Mahidol University. Faculty of Science. Center for Neuroscience and Department of Pharmacology
Mahidol University. Faculty of Medicine Siriraj Hospital. Department of Anatomy
Keywords: Hydrogen Peroxide;Toxicity Induces;Ras Signaling;Human Neuroblastoma;SH-SY5Y;Cultured Cells;Open Access article
Issue Date: 2010
Citation: Journal of Biomedicine and Biotechnology. 2010, ID 803815
Abstract: It has been reported that overproduction of reactive oxygen species occurs after brain injury and mediates neuronal cells degeneration. In the present study, we examined the role of Ras signaling on hydrogen peroxide-induced neuronal cells degeneration in dopaminergic neuroblastoma SH-SY5Y cells. Hydrogen peroxide significantly reduced cell viability in SH-SY5Y cultured cells. An inhibitor of the enzyme that catalyzes the farnesylation of Ras proteins, FTI-277, and a competitive inhibitor of GTP-binding proteins, GDP-beta-S significantly decreased hydrogen peroxide-induced reduction in cell viability in SH-SY5Y cultured cells. The results of this study might indicate that a Ras-dependent signaling pathway plays a role in hydrogen peroxideinduced toxicity in neuronal cells.
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