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Title: Prenatal and postnatal diagnoses of thalassemias and hemoglobinopathies by HPLC
Authors: Suthat Fucharoen
Pranee Winichagoon
Raewadee Wisedpanichkij
Busara Sae-Ngow
Rungrat Sriphanich
Warangkana Oncoung
Wanna Muangsapaya
Jew Chowthaworn
Sujin Kanokpongsakdi
Ahnond Bunyaratvej
Anong Piankijagum
Chris Dewaele
Mahidol University
Bio-Rad Laboratories
The Institute of Science and Technology for Research and Development, Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 29-Apr-1998
Citation: Clinical Chemistry. Vol.44, No.4 (1998), 740-748
Abstract: The conventional approach to qualitative and quantitative analyses of hemoglobin (Hb) molecules for the diagnoses of hemoglobinopathies requires a combination of tests. We used an automated HPLC (VARIANT(TM)) system to study α-thalassemia and β-thalassemia syndromes in Thailand. The beta-thalassemia short program is applicable to the diagnosis of α-thalassemia and β- thalassemia disorders, including Hb H, EA Bart's disease, and EF Bart's disease, in adults, newborns, and fetuses. The system cannot quantify accurately certain Hb molecules, such as Hb H and Hb Bart's. The alpha- thalassemia short program was therefore developed and used to quantify Hb Bart's to detect α-thalassemia genotypes in cord blood. This automated HPLC system is an alternative approach to the diagnosis of complicated thalassemia syndromes in Thailand and Southeast Asia.
ISSN: 00099147
Appears in Collections:Scopus 1991-2000

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