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Title: New compounds with DNA strand-scission activity from the combined leaf and stem of Uvaria hamiltonii
Authors: Li Huang
Monroe E. Wall
Mansukh C. Wani
Hernán Navarro
Thawatchai Santisuk
Vichai Reutrakul
Eun Kyoung Seo
Norman R. Farnsworth
A. Douglas Kinghorn
RTI International
The Forest Herbarium, Thailand Ministry of Natural Resources and Environment
Mahidol University
University of Illinois at Chicago
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Apr-1998
Citation: Journal of Natural Products. Vol.61, No.4 (1998), 446-450
Abstract: Two flavanones, hamiltones A (1) and B (2), an aurone, hamiltrone (3), a chalcone, hamilcone (4), and a tetrahydroxanthene, hamilxanthene (5), were isolated from Uvaria hamiltonii extracts guided initially by fractionation based on DNA strand-scission and/or 9KB cytotoxicity assays. Compounds 2-5 have not been reported previously, while 1 is new as a natural product. Structural assignments were made based on extensive spectroscopic measurements. Compounds 1-3 were inactive in the 9KB cytotoxicity assay, with compounds 4 and 5 having weak activity. In the DNA strand-scission assay, 3 was the most active compound found in the DNA strand-scission assay, being 10 times more potent than 1 or 2. Compound 4 was only weakly active, and 5 was inactive.
ISSN: 01633864
Appears in Collections:Scopus 1991-2000

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