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|Title:||New compounds with DNA strand-scission activity from the combined leaf and stem of Uvaria hamiltonii|
Monroe E. Wall
Mansukh C. Wani
Eun Kyoung Seo
Norman R. Farnsworth
A. Douglas Kinghorn
The Forest Herbarium, Thailand Ministry of Natural Resources and Environment
University of Illinois at Chicago
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Journal of Natural Products. Vol.61, No.4 (1998), 446-450|
|Abstract:||Two flavanones, hamiltones A (1) and B (2), an aurone, hamiltrone (3), a chalcone, hamilcone (4), and a tetrahydroxanthene, hamilxanthene (5), were isolated from Uvaria hamiltonii extracts guided initially by fractionation based on DNA strand-scission and/or 9KB cytotoxicity assays. Compounds 2-5 have not been reported previously, while 1 is new as a natural product. Structural assignments were made based on extensive spectroscopic measurements. Compounds 1-3 were inactive in the 9KB cytotoxicity assay, with compounds 4 and 5 having weak activity. In the DNA strand-scission assay, 3 was the most active compound found in the DNA strand-scission assay, being 10 times more potent than 1 or 2. Compound 4 was only weakly active, and 5 was inactive.|
|Appears in Collections:||Scopus 1991-2000|
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