Please use this identifier to cite or link to this item:
|Title:||Fabrication of multiunit controlled-release phenylpropanolamine hydrochloride tablets|
|Keywords:||Chemistry;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Drug Development and Industrial Pharmacy. Vol.24, No.8 (1998), 793-796|
|Abstract:||Phenylpropanolamine hydrochloride (PPA) pellets were prepared in a fluidized-bed rotary granulator. Microcrystalline cellulose and distilled water were used as pelletization enhancer and binder, respectively. The pellets were coated with methacrylate ester copolymer (Eudragit(R) RS 100) solution containing a 1:1 ratio mixture of triethyl citrate and castor oil as plasticizers. The addition of approximately 30% microcrystalline cellulose and 2% croscarmellose sodium to the 50% coated pellets produced fast disintegrating tablets. Dissolution profiles of both pellets and their respective matrix tablets were comparable and conformed to the USP dissolution requirement for PPA extended-release capsules.|
|Appears in Collections:||Scopus 1991-2000|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.