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Title: Fabrication of multiunit controlled-release phenylpropanolamine hydrochloride tablets
Authors: Ampol Mitrevej
Nuttanan Sinchaipanid
Nuttawat Natpoolwat
Narakorn Naratikornrit
Mahidol University
Keywords: Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-1998
Citation: Drug Development and Industrial Pharmacy. Vol.24, No.8 (1998), 793-796
Abstract: Phenylpropanolamine hydrochloride (PPA) pellets were prepared in a fluidized-bed rotary granulator. Microcrystalline cellulose and distilled water were used as pelletization enhancer and binder, respectively. The pellets were coated with methacrylate ester copolymer (Eudragit(R) RS 100) solution containing a 1:1 ratio mixture of triethyl citrate and castor oil as plasticizers. The addition of approximately 30% microcrystalline cellulose and 2% croscarmellose sodium to the 50% coated pellets produced fast disintegrating tablets. Dissolution profiles of both pellets and their respective matrix tablets were comparable and conformed to the USP dissolution requirement for PPA extended-release capsules.
ISSN: 03639045
Appears in Collections:Scopus 1991-2000

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