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|Title:||Characterization of sera from subjects infected with HIV-1 subtypes B and E in Thailand by antibody binding and neutralization|
T. D. Mastro
Imperial College London
Centers for Disease Control and Prevention
Bamrasnaradura Infectious Disease Institute
|Keywords:||Immunology and Microbiology;Medicine|
|Citation:||Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. Vol.19, No.4 (1998), 315-320|
|Abstract:||The range and specificity of the humoral immune response to HIV-1 subtypes B and E was investigated in Thai samples. Sera from HIV-1-positive subjects, consisting of subtypes B (n = 24) and E (n = 138), were characterized in relation to the neutralization of primary isolates and T- cell line-adapted (TCLA) strains and binding to monomeric gp120, the CD4/gp120 binding site (BS), and V3 peptides. A subtype-specific pattern of antibody binding was observed with the exception of the CD4/gp120(MN) BS. Neutralization of TCLA strains (n = 4) was strongly type-specific (p = .002); however, neutralization of primary isolates (n = 8) was weak and group specific. Thus, the subtype specificity of B and E sera in the neutralization of TCLA strains, but not primary isolates, supports the dominance of the V3 region in TCLA virus neutralization but does no(support the distinction of subtypes B and E as discrete neutralization serotypes in Thailand.|
|Appears in Collections:||Scopus 1991-2000|
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