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Title: Complete nucleotide sequence of pSK41: Evolution of staphylococcal conjugative multiresistance plasmids
Authors: Tracey Berg
Neville Firth
Sumalee Apisiridej
Anusha Hettiaratchi
Amornrut Leelaporn
Ronald A. Skurray
The University of Sydney
Prince of Songkla University
Mahidol University
Keywords: Immunology and Microbiology
Issue Date: 1-Sep-1998
Citation: Journal of Bacteriology. Vol.180, No.17 (1998), 4350-4359
Abstract: The 46.4-kb nucleotide sequence of pSK41, a prototypical multiresistance plasmid from Staphylococcus aureus, has been determined, representing the first completely sequenced conjugative plasmid from a gram-positive organism. Analysis of the sequence has enabled the identification of the probable replication, maintenance, and transfer functions of the plasmid and has provided insights into the evolution of a clinically significant group of plasmids. The basis of deletions commonly associated with pSK41 family plasmids has been investigated, as has the observed insertion site specificity of Tn552-like β-lactamase transposons within them. Several of the resistance determinants carried by pSK41-like plasmids were found to be located on up to four smaller cointegrated plasmids. pSK41 and related plasmids appear to represent a consolidation of antimicrobial resistance functions, collected by a preexisting conjugative plasmid via transposon insertion and IS257-mediated cointegrative capture of other plasmids.
ISSN: 00219193
Appears in Collections:Scopus 1991-2000

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