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Title: V3 sequence diversity of HIV-1 subtype E in infected mothers and their infants
Authors: Ruengpung Sutthent
Suporn Foongladda
Sanay Chearskul
Niran Wanprapa
Sirirat Likanonskul
Uraiwan Kositanont
Suda Riengrojpitak
Somphong Sahaphong
Chantapong Wasi
Mahidol University
Bamrasnaradura Hospital
Faculty of Medicine, Siriraj Hospital, Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Aug-1998
Citation: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. Vol.18, No.4 (1998), 323-331
Abstract: To elucidate genetic characteristics of HIV-1 subtype E involved in vertical transmission, V3 regions of HIV-1 subtype E isolated from 17 infected mothers (M1-M17) and their infants (I1-I17) at 1 month after birth were sequenced after cloned into pCRII vectors. At least three clones of each sample were collected. All mothers were asymptomatic and had been infected through a heterosexual route. Nine infants (I9-I17) showed mild symptomatic and immunosuppression within the first year of life. The interpatient nucleotide distance of mothers and infants in this group (0.065 ± 0.008) were of greater diversity than those of a nonimmunosuppression group (0.039 ± 0.006) by a significant amount (Fischer's exact test, p = .003). The substitution with asparagine (N) at threonine (T) at position 13 and aspartic acid (D) at position 29 of the V3 sequence were significantly associated with nonimmunosuppression in the first year of life (F-test, p = 0.003). Either a single or multiple viral variants could transmit from mothers to their infants.
ISSN: 10779450
Appears in Collections:Scopus 1991-2000

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