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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/18380
Title: A comparison of three different dihydroartemisinin formulations for the treatment of acute uncomplicated falciparum malaria in Thailand
Authors: P. Wilairatana
P. Chanthavanich
P. Singhasivanon
S. Treeprasertsuk
S. Krudsood
K. Chalermrut
C. Phisalaphong
K. Kraisintu
S. Looareesuwan
Dept. of Clinical Tropical Medicine
The Hospital for Tropical Diseases, Bangkok
Thailand Government Pharmaceutical Organization
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Aug-1998
Citation: International Journal for Parasitology. Vol.28, No.8 (1998), 1213-1218
Abstract: We compared the safety and efficacy of three formulations of dihydroartemisinin for the treatment of acute uncomplicated falciparum malaria in patients who received a total dose of 600 mg dihydroartemisinin over 5 days. The first group was treated by dihydroartemisinin produced and formulated in the People's Republic of China, the second group was treated by dihydroartemisinin produced in Vietnam but formulated by the Government Pharmaceutical Organization of Thailand and the third group was treated by dihydroartemisinin produced and formulated by the Government Pharmaceutical Organization of Thailand. All patients were admitted to hospital to evaluate safety and efficacy for a total of 28 days. By the third day of treatment, most patients were blood-smear negative for parasites and none had serious adverse effects. Minor symptoms such as nausea, dizziness and headache were similar in the three groups and disappeared after 3 days of treatment. One-hundred and thirty-three patients completed the 28-day follow-up period. The cure rates of group I, II and III were 80%, 85% and 92%, respectively (P > 0.02). There were no significant differences in fever clearance or parasite clearance among the three groups. We conclude that the three formulations of dihydroartemisinin produced and formulated in different countries were safe and effective in treating uncomplicated falciparum malaria acquired in Thailand.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0031867419&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/18380
ISSN: 00207519
Appears in Collections:Scopus 1991-2000

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