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dc.contributor.authorWanpen Chaicumpaen_US
dc.contributor.authorManas Chongsa-Nguanen_US
dc.contributor.authorThareerat Kalambahetien_US
dc.contributor.authorPolrat Wilairatanaen_US
dc.contributor.authorPotjanee Srimanoteen_US
dc.contributor.authorYuvadee Makakunkijcharoenen_US
dc.contributor.authorSornchai Looareesuwanen_US
dc.contributor.authorYuwaporn Sakolvareeen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationVaccine. Vol.16, No.7 (1998), 678-684en_US
dc.description.abstractA mixture of Vibrio cholerae antigens made up of crude fimbrial extract, lipopoly-saccharide and procholeragenoid was administered orally to Thai volunteers either as free antigen or associated with liposomes. All vaccinees and controls were administered in three doses given at 14 day intervals. Nine volunteers received liposome-associated vaccine and seven received free vaccine. Liposomes without antigens were given to eight volunteers and seven volunteers received 5% NaHCO3solution alone. Both vaccines had 100% immunogenicity as determined by serum vibriocidal antibody responses. Liposomes were shown by indirect ELISA to localize the immune response against lipopolysaccharide and fimbriae to the intestinal mucosa. Vaccinees given liposome-associated antigens had a higher rate of antigen-specific antibody response than did individuals who had received free antigens. The vaccines induced intestinal antibodies of IgM and/or IgA isotypes, but not IgG antibody.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleImmunogenicity of liposome-associated and refined antigen oral cholera vaccines in Thai volunteersen_US
Appears in Collections:Scopus 1991-2000

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