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Title: Immunogenicity of liposome-associated and refined antigen oral cholera vaccines in Thai volunteers
Authors: Wanpen Chaicumpa
Manas Chongsa-Nguan
Thareerat Kalambaheti
Polrat Wilairatana
Potjanee Srimanote
Yuvadee Makakunkijcharoen
Sornchai Looareesuwan
Yuwaporn Sakolvaree
Mahidol University
Keywords: Immunology and Microbiology;Medicine;Veterinary
Issue Date: 1-Apr-1998
Citation: Vaccine. Vol.16, No.7 (1998), 678-684
Abstract: A mixture of Vibrio cholerae antigens made up of crude fimbrial extract, lipopoly-saccharide and procholeragenoid was administered orally to Thai volunteers either as free antigen or associated with liposomes. All vaccinees and controls were administered in three doses given at 14 day intervals. Nine volunteers received liposome-associated vaccine and seven received free vaccine. Liposomes without antigens were given to eight volunteers and seven volunteers received 5% NaHCO3solution alone. Both vaccines had 100% immunogenicity as determined by serum vibriocidal antibody responses. Liposomes were shown by indirect ELISA to localize the immune response against lipopolysaccharide and fimbriae to the intestinal mucosa. Vaccinees given liposome-associated antigens had a higher rate of antigen-specific antibody response than did individuals who had received free antigens. The vaccines induced intestinal antibodies of IgM and/or IgA isotypes, but not IgG antibody.
ISSN: 0264410X
Appears in Collections:Scopus 1991-2000

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