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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/1848
Title: Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation.
Authors: Kwissa Marcin
Nakaya, Helder I.
Nattawat Onlamoon
Wrammert Jens
Villinger Francois
Perng, Guey Chuen
Sutee Yoksan
Kovit Pattanapanyasat
Kulkanya Chokephaibulkit
Ahmed Rafi
Pulendran Bali
Mahidol University. Faculty of Medicine Siriraj Hospital. Insitute of Molecular Biosciences
Mahidol University. Faculty of Medicine Siriraj Hospital. Department of Pediatrics
Keywords: Dengue;virus;CD14+;CD16+;monocyte;Dengue virus;Open Access article
Issue Date: 9-Jul-2014
Citation: Cell Host Microbe. Vol.16, No.1 (2014), 115–127.
Abstract: Dengue virus (DENV) infection induces the expansion of plasmablasts, which produce antibodies that can neutralize DENV but also enhance disease upon secondary infection with another DENV serotype. To understand how these immune responses are generated, we used a systems biological approach to analyze immune responses to dengue in humans. Transcriptomic analysis of whole blood revealed that genes encoding proinflammatory mediators and type I interferon-related proteins were associated with high DENV levels during initial symptomatic disease. Additionally, CD14(+)CD16(+) monocytes increased in the blood. Similarly, in a nonhuman primate model, DENV infection boosted CD14(+)CD16(+) monocyte numbers in the blood and lymph nodes. Upon DENV infection in vitro, monocytes upregulated CD16 and mediated differentiation of resting B cells to plasmablasts as well as immunoglobulin G (IgG) and IgM secretion. These findings provide a detailed picture of innate responses to dengue and highlight a role for CD14(+)CD16(+) monocytes in promoting plasmablast differentiation and anti-DENV antibody responses.
URI: http://repository.li.mahidol.ac.th/dspace/handle/123456789/1848
metadata.dc.identifier.url: http://www.sciencedirect.com/science/article/pii/S1931312814001917
http://www.ncbi.nlm.nih.gov/pubmed/24981333
Appears in Collections:MB-Article

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