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dc.contributor.authorSirirat Likanonsakulen_US
dc.contributor.authorChantapong Wasien_US
dc.contributor.authorCharin Thepthaien_US
dc.contributor.authorRuengpung Sutthenten_US
dc.contributor.authorSuda Louisirirotchanakulen_US
dc.contributor.authorSanay Chearskulen_US
dc.contributor.authorNiran Vanprapaen_US
dc.contributor.authorTasanee Lebnarken_US
dc.contributor.otherBamrasnaradura Hospitalen_US
dc.contributor.otherFaculty of Medicine, Siriraj Hospital, Mahidol Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationSoutheast Asian Journal of Tropical Medicine and Public Health. Vol.29, No.3 (1998), 453-463en_US
dc.description.abstractThe results of CD4+, CD8+T- lymphocyte values as percentage, number, and ratio were studied in infants aged 1 to 29 months. The 283 subsequent blood samples from 89 infants born to HIV-1 seropositive mothers were investigated. From 208 sequential samples of 70 healthy non-infected infants, the reference values of CD4+and CD8+T-lymphocytes have been established and compared to Caucasian reference values. The results were analysed in 4 difference age groups (1-5, 6-11, 12-17 and ≥ 18 months). At age 12 months, CD4 number and percentage declined significantly while CD8 percent increased. At age 6 months CD4/CD8 ratio decreased. Of 19 infected infants CD4+percentage and number as well as CD4/ CD8 ratio declined at age 6 months and showed significant differences from uninfected infants. A significantly elevated CD8 percentage was demonstrated in infected infants at age of 12 months. In 9 infants who showed symptoms at age 6-18 months, the CD4 and CD8 values were different from the reference range and 6 of 9 patients showed lower CD4 percentage, CD4 number and reversed CD4/CD8 ratio before the symptoms appeared. In 10 infants who were asymptomatic at age 18 months, there was no evidence of immunosuppression at age 6 months or before. After age 6 months, lymphocyte subset values of some asymptomatic infected children were beyond the reference range. These preliminary findings should be very useful for monitoring children born to HIV infected mothers. The results of CD4+and CD8+T-lymphocytes in uninfected infants could be used as reference values for the Thai and other Southeast Asian pediatric populations.en_US
dc.rightsMahidol Universityen_US
dc.titleThe reference range of CD4<sup>+</sup>and CD8<sup>+</sup>T-lymphocytes in healthy non-infected infants born to HIV-1 seropositive mothers; A preliminary study at Siriraj Hospitalen_US
Appears in Collections:Scopus 1991-2000

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