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Title: Impediment of the Progressions of Microalbuminuria and Hyperlipidemia in Normotensive Type 2 Diabetes by Low-Dose Ramipril
Authors: Somboon Vongterapak
Soontaree Nakasatien
Monta Suppanich
Chanika Surasingchaidet
Mayura Tepkasetkul
Boonsong Ongphiphadhanakul
Thep Himathongkam
Winai Dahlan
Tawee Anuntakulnatee
Worawit Kittipoom
Chattip Tamwiwat
Pongamorn Bunnag
Rajata Rajatanavin
Theptarin General Hospital
Chulalongkorn University
Mahidol University
Keywords: Medicine
Issue Date: 1-Sep-1998
Citation: Journal of the Medical Association of Thailand. Vol.81, No.9 (1998), 670-680
Abstract: In a randomized, double-blind, placebo-controlled study, we investigated in normotensive type 2 diabetics with microalburninuria the effect of ramipril, an ACE inhibitor, on urine albumin excretion and serum lipids. A total of 1,882 patients were screened for urine microalbumin consecutively by dipstick test, Rapi Tex®-Albumin test and RIA. The final 28 normotensive and microalbuminuric patients were assigned to receive either ramipril (1.25 mg/d, n=16) or placebo (n=12) for 12 weeks. Throughout the study, both groups had no changes in blood pressure, fasting plasma glucose, HbA1C, serum creatinine and electrolytes and no difference in creatinine clearance. At week 12 only the placebo group showed the significant increment of urine albumin excretion and triacylglycerol (30.6±38.3 to 39.0±19.7 and 167±64 to 208±77 mg/dl, respectively) but the decrement of HDL-cholesterol (46±16 to 35±6 mg/dl). During a 3 month period, increased urine albumin excretion was observed in normotensive type 2 diabetes with microalbuminuria who received only placebo. We conclude that ramipril may arrest the progression of albumin excretion and had favorable effects on serum lipids. Ramipril was safe and well-tolerated without untoward side effects during the study period.
ISSN: 01252208
Appears in Collections:Scopus 1991-2000

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