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Title: Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways.
Authors: Anorut Jenwitheesuk
Chutikorn Nopparat
Sujira Mukda
Prapimpun Wongchitrat
Piyarat Govitrapong
Mahidol University. Institute of Molecular Biosciences. Research Center for Neuroscience
Mahidol University. Faculty of Medical Technology. Center for Innovation Development and Technology Transfer
Mahidol University. Faculty of Science. Center for Neuroscience and Department of Pharmacology
Keywords: Melatonin;Brain aging;Energy metabolism;Epigenetics;Autophagy;Ccircadian rhythm;Neurodegeneration;Sirtuins;Open Access article
Issue Date: 2014
Citation: International Journal of Molecular Sciences. Vol.15, No.9 (2014), 16848-16884
Abstract: Brain aging is linked to certain types of neurodegenerative diseases and identifying new therapeutic targets has become critical. Melatonin, a pineal hormone, associates with molecules and signaling pathways that sense and influence energy metabolism, autophagy, and circadian rhythms, including insulin-like growth factor 1 (IGF-1), Forkhead box O (FoxOs), sirtuins and mammalian target of rapamycin (mTOR) signaling pathways. This review summarizes the current understanding of how melatonin, together with molecular, cellular and systemic energy metabolisms, regulates epigenetic processes in the neurons. This information will lead to a greater understanding of molecular epigenetic aging of the brain and anti-aging mechanisms to increase lifespan under healthy conditions.
metadata.dc.identifier.url: file:///C:/Users/AcerM4610G/Downloads/ijms-15-16848.pdf
ISSN: 1422-0067
Appears in Collections:MB-Article

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