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dc.contributor.authorAnorut Jenwitheesuken_US
dc.contributor.authorChutikorn Nopparaten_US
dc.contributor.authorSujira Mukdaen_US
dc.contributor.authorPrapimpun Wongchitraten_US
dc.contributor.authorPiyarat Govitrapongen_US
dc.contributor.otherMahidol University. Institute of Molecular Biosciences. Research Center for Neuroscience-
dc.contributor.otherMahidol University. Faculty of Medical Technology. Center for Innovation Development and Technology Transfer-
dc.contributor.otherMahidol University. Faculty of Science. Center for Neuroscience and Department of Pharmacology-
dc.identifier.citationInternational Journal of Molecular Sciences. Vol.15, No.9 (2014), 16848-16884en_US
dc.description.abstractBrain aging is linked to certain types of neurodegenerative diseases and identifying new therapeutic targets has become critical. Melatonin, a pineal hormone, associates with molecules and signaling pathways that sense and influence energy metabolism, autophagy, and circadian rhythms, including insulin-like growth factor 1 (IGF-1), Forkhead box O (FoxOs), sirtuins and mammalian target of rapamycin (mTOR) signaling pathways. This review summarizes the current understanding of how melatonin, together with molecular, cellular and systemic energy metabolisms, regulates epigenetic processes in the neurons. This information will lead to a greater understanding of molecular epigenetic aging of the brain and anti-aging mechanisms to increase lifespan under healthy conditions.en_US
dc.rightsMahidol Universityen_US
dc.subjectBrain agingen_US
dc.subjectEnergy metabolismen_US
dc.subjectCcircadian rhythmen_US
dc.subjectOpen Access articleen_US
dc.titleMelatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways.en_US
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