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Title: Serological evaluation of malaria patients in Thailand: Antibody response against electrophoresed antigenic polypeptides of Plasmodium falciparum
Authors: Shigeyuki Kano
Tomoko Onda
Yoshitsugu Matsumoto
Kasinee Buchachart
Srivicha Krudsood
Sornchai Looareesuwan
Masamichi Aikawa
Mamoru Suzuki
Gunma University Faculty of Medicine
University of Tokyo
Mahidol University
Tokai University
Keywords: Medicine
Issue Date: 1-Jun-1998
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.29, No.2 (1998), 341-343
Abstract: It was reported that a 47kDa antigenic polypeptide of Plasmodium falciparum had been strongly presented by the sera from 1) imported Japanese malaria patients with severe symptoms and 2) symptomatic and parasitemic inhabitants in endemic areas in the Sudan, Malaysia and the Philippines. In the present study, we observed the reactivity of the sera from falciparum malaria patients who had been hospitalized in the Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, and compared the antibody response against the 47kDa antigenic polypeptide according to the severity of the patients. It was observed that antibodies to this molecule were more commonly shared in sera from severer patients, although the IFAT titers against the whole P.falciparum parasite antigen were lower in the group, which suggested that this antibody against the 47kDa molecule was playing a specific role at a severe stage of the infection. Determination of the immunological features of the antigenic molecules of parasites by this type of sero-epidemiological study will provide a new assay system for evaluation of immune status of individuals in different severity and suggest a way of vaccine development.
ISSN: 01251562
Appears in Collections:Scopus 1991-2000

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