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Title: K-ras oncogene and p53 gene mutations in cholangiocarcinoma from Thai patients
Authors: Songsak Petmitr
Somchai Pinlaor
Ampai Thousungnoen
Anant Karalak
Panata Migasena
Mahidol University
National Cancer Institute Thailand
Keywords: Medicine
Issue Date: 1-Mar-1998
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.29, No.1 (1998), 71-75
Abstract: Paraffin embedded tisues from twenty Thai patients with intrahepatic cholangiocarcinomas were studied forK-ras gene mutations at codon 12,13 and 61 and for p53 gene mutations in exon 5 to 8 using polymerase chain reaction and thermal cycle sequencing. Results showed that point mutations at these regions in K-ras oncogene were not present in all the samples. One case harbored ap53 gene mutation in codon 282 in exon 8, CGG (arginine) to TGG (tryptophan), but the mutation was not found in other patient's tissues with similar histological features.
ISSN: 01251562
Appears in Collections:Scopus 1991-2000

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