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dc.contributor.authorM. Van Vugten_US
dc.contributor.authorA. Brockmanen_US
dc.contributor.authorB. Gemperlien_US
dc.contributor.authorC. Luxemburgeren_US
dc.contributor.authorI. Gathmannen_US
dc.contributor.authorC. Royceen_US
dc.contributor.authorThra Slighten_US
dc.contributor.authorS. Looareesuwanen_US
dc.contributor.authorN. J. Whiteen_US
dc.contributor.authorF. Nostenen_US
dc.contributor.otherShoklo Malaria Research Uniten_US
dc.contributor.otherAcademic Medical Centre, University of Amsterdamen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNovartis International AGen_US
dc.contributor.otherJohn Radcliffe Hospitalen_US
dc.identifier.citationAntimicrobial Agents and Chemotherapy. Vol.42, No.1 (1998), 135-139en_US
dc.description.abstractAn open, randomized comparison of artemether-benflumetol (CGP 56 697; Novartis) with artesunate-mefloquine was conducted in 617 patients with acute uncomplicated multidrug-resistant falciparum malaria on the western border of Thailand. Both treatments rapidly and reliably cleared fever and parasitemia, and there was no significant difference in the initial therapeutic response parameters. Parasite genotyping was used to distinguish recrudescences from new infections. The 63-day cure rate for artesunate-mefloquine (94%) was significantly higher than the cure rate for artemether-benflumetol (81%) (P < 0.001). Both regimens were well tolerated. Nausea, vomiting, dizziness, sleep disorders, and other neurological side effects were between two and four times more common in the artesunate-mefloquine group than in the artemether- benflumetol group (P < 0.001). Artemether-benflumetol is effective and very well tolerated in the treatment of multidrug-resistant falciparum malaria. A higher dose than that used in the present study may improve efficacy.en_US
dc.rightsMahidol Universityen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleRandomized comparison of artemether-benflumetol and artesunate- mefloquine in treatment of multidrug-resistant falciparum malariaen_US
Appears in Collections:Scopus 1991-2000

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