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Title: Possible mechanism of hypoglycemic effect of 4-hydroxybenzoic acid, a constituent of Pandanus odorus root
Authors: Penchom Peungvicha
Suwan S. Thirawarapan
Hiroshi Watanabe
Mahidol University
University of Toyama
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Nov-1998
Citation: Japanese Journal of Pharmacology. Vol.78, No.3 (1998), 395-398
Abstract: We studied the hypoglycemic effect of 4-hydroxybenzoic acid, a constituent of the root of Pandanus odorus Ridl. (Pandanaceae, Thai name: Toei-hom), in streptozotocin-diabetic rats. Oral administration of 4-hydroxybenzoic acid caused a decrease in plasma glucose levels dose-dependently in the diabetic rat. The constituent did not affect serum insulin level and liver glycogen content in the diabetic model, but increased glucose consumption in normal and diabetic rat diaphragms. These results suggest that 4-hydroxybenzoic acid produces a hypoglycemic effect mediated by an increase in the peripheral glucose consumption.
ISSN: 00215198
Appears in Collections:Scopus 1991-2000

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