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Title: Heritability of P. falciparum and P. vivax Malaria in a Karen population in Thailand
Authors: Waraphon Phimpraphil
Richard Paul
Bhee Witoonpanich
Chairat Turbpaiboon
Chayanon Peerapittayamongkol
Chalisa Louicharoen
Isabelle Casademont
Sumalee Tungpradabkul
Srivicha Krudsood
Jaranit Kaewkunwal
Thanyachai Sura
Sornchai Looareesuwan
Pratap Singhasivanon
Anavaj Sakuntabhai
Institut Pasteur, Paris
Mahidol University
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 8-Dec-2008
Citation: PLoS ONE. Vol.3, No.12 (2008)
Abstract: The majority of studies concerning malaria host genetics have focused on individual genes that confer protection against rather than susceptibility to malaria. Establishing the relative impact of genetic versus non-genetic factors on malaria infection and disease is essential to focus effort on key determinant factors. This relative contribution has rarely been evaluated for Plasmodium falciparum and almost never for Plasmodium vivax. We conducted a longitudinal cohort study in a Karen population of 3,484 individuals in a region of mesoendemic malaria, Thailand from 1998 to 2005. The number of P. falciparum and P. vivax clinical cases and the parasite density per person were determined. Statistical analyses were performed to account for the influence of environmental factors and the genetic heritability of the phenotypes was calculated using the pedigree-based variance components model. The genetic contribution to the number of clinical episodes resulting from P. falciparum and P. vivax were 10% and 19% respectively. There was also moderate genetic contribution to the maximum and overall parasite trophozoite density phenotypes for both P. falciparum (16%&16%) and P. vivax (15%&13%). These values, for P. falciparum, were similar to those previously observed in a region of much higher transmission intensity in Senegal, West Africa. Although environmental factors play an important role in acquiring an infection, genetics plays a determinant role in the outcome of an infection with either malaria parasite species prior to the development of immunity. © 2008 Phimpraphi et al.
ISSN: 19326203
Appears in Collections:Scopus 2006-2010

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