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Title: Lack of association of the HbE variant with protection from cerebral malaria in Thailand
Authors: Izumi Naka
Jun Ohashi
Pornlada Nuchnoi
Hathairad Hananantachai
Sornchai Looareesuwan
Katsushi Tokunaga
Jintana Patarapotikul
University of Tokyo
University of Tsukuba
Mahidol University
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Dec-2008
Citation: Biochemical Genetics. Vol.46, No.11-12 (2008), 708-711
Abstract: Hemoglobin E (HbE;β26Glu → Lys) is the most common variant of the β-globin gene in Southeast Asia; it has been suggested that it confers resistance against Plasmodium falciparum malaria. In this study 306 adult patients with P. falciparum malaria (198 mild and 108 cerebral malaria patients) living in northwest Thailand were investigated to examine whether the HbE variant is associated with protection from cerebral malaria. Our results revealed that the sample allele frequency of HbE was not significantly different between mild (7.3%) and cerebral malaria (7.4%) patients. Thus, the HbA/HbE polymorphism would not be a major genetic factor influencing the onset of cerebral malaria in Thailand. © 2008 Springer Science+Business Media, LLC.
ISSN: 00062928
Appears in Collections:Scopus 2006-2010

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