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Title: Cytotoxic and antiplasmodial substances from marine-derived fungi, Nodulisporium sp. and CRI247-01
Authors: Chairut Kasettrathat
Nattaya Ngamrojanavanich
Suthep Wiyakrutta
Chulabhorn Mahidol
Somsak Ruchirawat
Prasat Kittakoop
Chulabhorn Research Institute
Chulalongkorn University
Mahidol University
The Institute of Science and Technology for Research and Development, Mahidol University
Keywords: Agricultural and Biological Sciences;Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Oct-2008
Citation: Phytochemistry. Vol.69, No.14 (2008), 2621-2626
Abstract: Nodulisporacid A (1) was isolated from a marine-derived fungus Nodulisporium sp. CRIF1, while vermelhotin (5) was obtained from an unidentified fungus CRI247-01 (a member of the Order Pleosporales). Both 1 and 5 occurred as equilibrium E/Z mixtures. Ester derivatives (2 and 3) and vermelhotin (5) showed cytotoxic activity against eleven cancer cell lines. Nodulisporacid A (1) and vermelhotin (5) exhibited moderate antiplasmodial activity. © 2008 Elsevier Ltd. All rights reserved.
ISSN: 00319422
Appears in Collections:Scopus 2006-2010

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