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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/18821
Title: Vasorelaxant and antioxidant activities of spilanthes acmella Murr
Authors: Orapin Wongsawatkul
Supaluk Prachayasittikul
Chartchalerm Isarankura-Na-Ayudhya
Jutamaad Satayavivad
Somsak Ruchirawat
Virapong Prachayasittikul
Srinakharinwirot University
Mahidol University
Chulabhorn Research Institute
Keywords: Biochemistry, Genetics and Molecular Biology;Chemical Engineering;Chemistry;Computer Science
Issue Date: 1-Dec-2008
Citation: International Journal of Molecular Sciences. Vol.9, No.12 (2008), 2724-2744
Abstract: This study reports the effect of Spilanthes acmella Murr. extracts on phenylephrine-induced contraction of rat thoracic aorta as well as their antioxidant activity. Results show that the extracts exert maximal vasorelaxations in a dose-dependent manner, but their effects are less than acetylcholine-induced nitric oxide (NO) vasorelaxation. Significant reduction of vasorelaxations is observed in both N G-nitro-L-arginine methyl ester (L-NAME) and indomethacin (INDO). In the presence of L-NAME plus INDO, synergistic effects are observed, leading to loss of vasorelaxation of both acetylcholine and the extracts. Similarly, the vasorelaxations of the extracts are completely abolished upon the removal of endothelial cells. This demonstrates that the extracts exhibit vasorelaxation via partially endothelium-induced NO and prostacyclin in a dose-dependent manner. Significantly, the ethyl acetate extract exerts immediate vasorelaxation (ED 50 76.1 ng/mL) and is the most potent antioxidant (DPPH assay). The chloroform extract shows the highest vasorelaxation and antioxidation (SOD assay). These reveal a potential source of vasodilators and antioxidants. © 2008.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=58149229380&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/18821
ISSN: 14220067
Appears in Collections:Scopus 2006-2010

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