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Title: Molecular epidemiological analysis of highly pathogenic avian influenza H5N1 subtype isolated from poultry and wild bird in Thailand
Authors: Yuko Uchida
Kridsada Chaichoune
Witthawat Wiriyarat
Chiaki Watanabe
Tsuyoshi Hayashi
Tuangthong Patchimasiri
Bandit Nuansrichay
Sujira Parchariyanon
Masatoshi Okamatsu
Kenji Tsukamoto
Nobuhiro Takemae
Parntep Ratanakorn
Shigeo Yamaguchi
Takehiko Saito
Thailand-Japan Zoonotic Diseases Collaboration Center
National Institute of Animal Health, NARO
Mahidol University
Thailand National Institute of Animal Health
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology;Medicine
Issue Date: 1-Dec-2008
Citation: Virus Research. Vol.138, No.1-2 (2008), 70-80
Abstract: A comprehensive molecular epidemiological analysis was performed on highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype derived from poultry and wild bird during 2004-2007 in Thailand. Sequence analysis followed by phylogenetic analysis was applied to all eight segments of the viruses. Viruses belonging to clades 1 and 2.3.4 in the HA phylogenetic tree have been shown to circulate in Thailand. Our analysis revealed differential evolution of the HPAI viruses among clade 1 strains. Isolates from Phichit province in 2006 resided in two distinct branches, designated 1.p1 and 1.p2. A hemagglutination inhibition test with a panel of monoclonal antibodies demonstrated a possible antigenic drift between the Phichit isolates. Involvement of free-grazing duck practice in the area was discussed as a cause of the differential evolution among the Phichit isolates. A branch, designated 1-TGWB and consisting exclusively of isolates from zoological tigers and wild birds, was evident in all phylogenetic trees constructed in the study. The branch's existence indicated that the HPAI viruses could have been maintained in the wild bird population for a certain period, although no involvement of wild birds in HPAI transmission to poultry was evident in this study. © 2008 Elsevier B.V. All rights reserved.
ISSN: 01681702
Appears in Collections:Scopus 2006-2010

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