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dc.contributor.authorPornlada Nuchnoien_US
dc.contributor.authorJun Ohashien_US
dc.contributor.authorIzumi Nakaen_US
dc.contributor.authorDuangporn Nacapunchaien_US
dc.contributor.authorKatsushi Tokunagaen_US
dc.contributor.authorNao Nishidaen_US
dc.contributor.authorJintana Patarapotikulen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Tokyoen_US
dc.contributor.otherNaresuan Universityen_US
dc.date.accessioned2018-07-12T02:17:29Z-
dc.date.available2018-07-12T02:17:29Z-
dc.date.issued2008-09-01en_US
dc.identifier.citationJournal of Human Genetics. Vol.53, No.9 (2008), 850-856en_US
dc.identifier.issn14345161en_US
dc.identifier.other2-s2.0-50249148885en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=50249148885&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/18869-
dc.description.abstractA number of loci related to the immune response are located on human chromosomal region 5q31-33, and polymorphisms in this region have been reported to be associated with autoimmune and infectious diseases. In Southeast Asian populations, no systematic survey with dense SNP markers has been performed for the 5q31-33 region. In this study, the LD and haplotype structures for a 472-kb region on 5q31 were investigated in a Thai population to provide useful information for association studies. In addition, the LD structure in Thais was compared with that of the CHB and JPT HapMap populations (CHB + JPT) to evaluate the transferability of tagging SNPs from CHB + JPT for Thais. We show that the minor allele frequency, pattern of LD block, and genetic structure in the 5q31-33 region were highly concordant between Thais and CHB + JPT. A high transferability of tagging SNPs from CHB + JPT for Thais was observed. Our results suggest that tagging SNPs from CHB + JPT (Northeast Asians) can efficiently capture common variants in Southeast Asians, and that the HapMap data are useful for association studies in Southeast Asian populations. © 2008 The Japan Society of Human Genetics and Springer.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=50249148885&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectMedicineen_US
dc.titleLinkage disequilibrium structure of the 5q31-33 region in a Thai populationen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1007/s10038-008-0309-8en_US
Appears in Collections:Scopus 2006-2010

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