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Title: 11-Hydroxymonocerin from the plant endophytic fungus Exserohilum rostratum
Authors: Ruengrit Sappapan
Damrong Sommit
Nattaya Ngamrojanavanich
Somchai Pengpreecha
Suthep Wiyakrutta
Nongluksna Sriubolmas
Khanitha Pudhom
Chulalongkorn University
Mahanakorn University of Technology
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Sep-2008
Citation: Journal of Natural Products. Vol.71, No.9 (2008), 1657-1659
Abstract: A new analogue of monocerin, 11-hydroxymonocerin (2), along with monocerin (1) and 12-hydroxymonocerin (3) were isolated from cultures of Exserohilum rostratum, a fungal strain endophytic in Stemona sp. The structure of 2 was determined by analysis of NMR and MS data and by comparison of spectroscopic data to those of 1. Monocerin (1) and 11-hydroxymonocerin (2) displayed activity against Plasmodium falciparum (K1, multidrug-resistant strain) with IC 50 values of 0.68 and 7.70 μM, respectively. None of the compounds were cytotoxic against any of the tumor cell lines tested. © 2008 American Chemical Society and American Society of Pharmacognosy.
ISSN: 01633864
Appears in Collections:Scopus 2006-2010

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