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|Title:||11-Hydroxymonocerin from the plant endophytic fungus Exserohilum rostratum|
Mahanakorn University of Technology
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Journal of Natural Products. Vol.71, No.9 (2008), 1657-1659|
|Abstract:||A new analogue of monocerin, 11-hydroxymonocerin (2), along with monocerin (1) and 12-hydroxymonocerin (3) were isolated from cultures of Exserohilum rostratum, a fungal strain endophytic in Stemona sp. The structure of 2 was determined by analysis of NMR and MS data and by comparison of spectroscopic data to those of 1. Monocerin (1) and 11-hydroxymonocerin (2) displayed activity against Plasmodium falciparum (K1, multidrug-resistant strain) with IC 50 values of 0.68 and 7.70 μM, respectively. None of the compounds were cytotoxic against any of the tumor cell lines tested. © 2008 American Chemical Society and American Society of Pharmacognosy.|
|Appears in Collections:||Scopus 2006-2010|
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