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dc.contributor.authorSontaya Limmatvapiraten_US
dc.contributor.authorChutima Limmatvapiraten_US
dc.contributor.authorSatit Puttipipatkhachornen_US
dc.contributor.authorJurairat Nunthaniden_US
dc.contributor.authorManee Luangtana-ananen_US
dc.contributor.authorPornsak Sriamornsaken_US
dc.contributor.otherSilpakorn Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-07-12T02:17:47Z-
dc.date.available2018-07-12T02:17:47Z-
dc.date.issued2008-08-01en_US
dc.identifier.citationEuropean Journal of Pharmaceutics and Biopharmaceutics. Vol.69, No.3 (2008), 1004-1013en_US
dc.identifier.issn09396411en_US
dc.identifier.other2-s2.0-48149099419en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=48149099419&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/18882-
dc.description.abstractA new oral-controlled release matrix tablet based on shellac polymer was designed and developed, using metronidazole (MZ) as a model drug. The shellac-based matrix tablets were prepared by wet granulation using different amounts of shellac and lactose. The effect of annealing temperature and pH of medium on drug release from matrix tablets was investigated. The increased amount of shellac and increased annealing temperature significantly affected the physical properties (i.e., tablet hardness and tablet disintegration) and MZ release from the matrix tablets. The in-situ polymerization played a major role on the changes in shellac properties during annealing process. Though the shellac did not dissolve in acid medium, the MZ release in 0.1 N HCl was faster than in pH 7.3 buffer, resulting from a higher solubility of MZ in acid medium. The modulation of MZ release kinetics from shellac-based matrix tablets could be accomplished by varying the amount of shellac or annealing temperature. The release kinetics was shifted from relaxation-controlled release to diffusion-controlled release when the amount of shellac or the annealing temperature was increased. © 2008 Elsevier B.V. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=48149099419&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleModulation of drug release kinetics of shellac-based matrix tablets by in-situ polymerization through annealing processen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1016/j.ejpb.2008.01.027en_US
Appears in Collections:Scopus 2006-2010

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